TOXICITY STUDY OF ACACIA NILOTICA POD EXTRACT ON ALBINO RATS

Abstract

ABSTRACT Acute toxicity study of Methanol pod extract of acacia nilotica did not produced any related signs of toxicity or mortality. The sub acute toxicity study showed a decrease in activity of ALP, AST and ALT of the methanol pod extract of acacia nilotica. For ALP there was significant different between animals administered with extract as compared to control which is( 188.0 ± 4.1) and (173.3 ± 5.28) respectively. For ALT there was significant different between group 2 (45.6 ± 1.03) group 3 (54.1 ± 1.48), group 4 (47.6 ± 0.63) and group 5 (52.9 ± 2.11) as compared to the control(21.8 ± 1.48), For AST there was no significant different between group 3 (170.8 ± 2.75) group 4 (178.0 ± 4.96) and group 5 (174.3± 3.35) but there was no significant different between group 1(155.1 ± 3.28) and group 2 (167.9 ± 3.16) respectively. ALT was significantly low in all the test groups compared to the control. The activity of AST in group 2 was not significant when compared to control but all other groups showed a significant increase in activities to the control. The result showed that acacia nilotica is a potent hepatotoxic substance. There is need for further research to identify the leading conpound responsible for the hepatotoxicity. .